TargetNet
P51639
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Function
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Database Links
| Database | Links |
|---|---|
| UniProt | P51639 |
| PDB | Not available |
| BioGrid | 247704 |
| BindingDB | P51639 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 639 |
| PharmGKB | Not available |
| KEGG | rno:25675 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25675 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9855 | 0.0013 |
| Accuracy | 0.943 | 0.0029 |
| Sensitivity | 0.9559 | 0.0046 |
| Specificity | 0.9322 | 0.0043 |
| BEDROC | 0.9893 | 0.0048 |
| MCC Threshold | 0.326 | N/A |
| MCC | 0.8945 | N/A |
| F-score Threshold | 0.326 | N/A |
| F-score | 0.943 | N/A |