TargetNet
P51452
Dual specificity protein phosphatase 3
Function
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Database Links
| Database | Links |
|---|---|
| UniProt | P51452 |
| PDB | 1J4X, 1VHR, 3F81 |
| BioGrid | 108178 |
| BindingDB | P51452 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA27526 |
| KEGG | hsa:1845 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1845 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8231 | 0.0092 |
| Accuracy | 0.7684 | 0.0098 |
| Sensitivity | 0.8269 | 0.0124 |
| Specificity | 0.7097 | 0.0143 |
| BEDROC | 0.8699 | 0.0245 |
| MCC Threshold | 0.454 | N/A |
| MCC | 0.5839 | N/A |
| F-score Threshold | 0.454 | N/A |
| F-score | 0.8059 | N/A |