P50579

Methionine aminopeptidase 2

Function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N- terminal Met-Val and Met-Thr sequences in vivo.

Database Links

Database	Links
UniProt	P50579
PDB	1B59, 1B6A, 1BN5, 1BOA, 1KQ0, 1KQ9, 1QZY, 1R58, 1R5G, 1R5H, 1YW7, 1YW8, 1YW9, 2ADU, 2EA2, 2EA4, 2GA2, 2OAZ
BioGrid	116184
BindingDB	P50579
DrugBank	DB00134
Guide to PHARMACOLOGY	1573
PharmGKB	PA30765
KEGG	hsa:10988
BioCyc	Not available
Entrez Gene (GeneID)	10988

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.979	0.0015
Accuracy	0.9616	0.0033
Sensitivity	0.9743	0.0045
Specificity	0.9484	0.0041
BEDROC	0.9942	0.0123
MCC Threshold	0.4	N/A
MCC	0.9304	N/A
F-score Threshold	0.4	N/A
F-score	0.9661	N/A

Downloads

R Model Object

Random Forest model object (.RData)

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Positive Set

SMILES string + affinity value (.tsv)

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TargetNet