TargetNet
P50406
5-hydroxytryptamine receptor 6
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.
Database Links
| Database | Links |
|---|---|
| UniProt | P50406 |
| PDB | Not available |
| BioGrid | 109594 |
| BindingDB | P50406 |
| DrugBank | DB00889, DB00904, DB06144 |
| Guide to PHARMACOLOGY | 11 |
| PharmGKB | PA29560 |
| KEGG | hsa:3362 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3362 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9846 | 6.9236 × 10-4 |
| Accuracy | 0.9488 | 0.0012 |
| Sensitivity | 0.9437 | 0.0024 |
| Specificity | 0.9548 | 0.002 |
| BEDROC | 0.9986 | 0.0012 |
| MCC Threshold | 0.494 | N/A |
| MCC | 0.9016 | N/A |
| F-score Threshold | 0.494 | N/A |
| F-score | 0.954 | N/A |