TargetNet
P50172
Corticosteroid 11-beta-dehydrogenase isozyme 1
Function
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
Database Links
| Database | Links |
|---|---|
| UniProt | P50172 |
| PDB | 1Y5M, 1Y5R, 3GMD |
| BioGrid | Not available |
| BindingDB | P50172 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | mmu:15483 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 15483 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9824 | 6.8976 × 10-4 |
| Accuracy | 0.959 | 0.0021 |
| Sensitivity | 0.9617 | 0.0026 |
| Specificity | 0.9562 | 0.0041 |
| BEDROC | 0.9936 | 0.0033 |
| MCC Threshold | 0.566 | N/A |
| MCC | 0.9214 | N/A |
| F-score Threshold | 0.504 | N/A |
| F-score | 0.9612 | N/A |