TargetNet
P49810
Presenilin-2
Function
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Database Links
| Database | Links |
|---|---|
| UniProt | P49810 |
| PDB | Not available |
| BioGrid | 111643 |
| BindingDB | P49810 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33856 |
| KEGG | hsa:5664 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5664 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9804 | 0.0039 |
| Accuracy | 0.9487 | 0.0062 |
| Sensitivity | 0.9596 | 0.0124 |
| Specificity | 0.9391 | 0.0057 |
| BEDROC | 0.9818 | 0.0071 |
| MCC Threshold | 0.424 | N/A |
| MCC | 0.9001 | N/A |
| F-score Threshold | 0.424 | N/A |
| F-score | 0.9474 | N/A |