Presenilin-1
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Database | Links |
---|---|
UniProt | P49768 |
PDB | 2KR6 |
BioGrid | 111642 |
BindingDB | P49768 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 2402 |
PharmGKB | PA33855 |
KEGG | hsa:5663 |
BioCyc | Not available |
Entrez Gene (GeneID) | 5663 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9746 | 0.002 |
Accuracy | 0.9284 | 0.0064 |
Sensitivity | 0.9391 | 0.0078 |
Specificity | 0.9182 | 0.0108 |
BEDROC | 0.9844 | 0.0122 |
MCC Threshold | 0.62 | N/A |
MCC | 0.8851 | N/A |
F-score Threshold | 0.588 | N/A |
F-score | 0.9391 | N/A |