TargetNet
P49759
Dual specificity protein kinase CLK1
Function
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Database Links
| Database | Links |
|---|---|
| UniProt | P49759 |
| PDB | 1Z57, 2VAG |
| BioGrid | 107606 |
| BindingDB | P49759 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1990 |
| PharmGKB | PA26594 |
| KEGG | hsa:1195 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1195 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7856 | 0.0088 |
| Accuracy | 0.7132 | 0.0087 |
| Sensitivity | 0.6536 | 0.0131 |
| Specificity | 0.7746 | 0.0157 |
| BEDROC | 0.9707 | 0.0143 |
| MCC Threshold | 0.792 | N/A |
| MCC | 0.5235 | N/A |
| F-score Threshold | 0.314 | N/A |
| F-score | 0.7164 | N/A |