TargetNet
P49682
C-X-C chemokine receptor type 3
Function
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response.
Database Links
| Database | Links |
|---|---|
| UniProt | P49682 |
| PDB | Not available |
| BioGrid | 109094 |
| BindingDB | P49682 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 70 |
| PharmGKB | PA35049 |
| KEGG | hsa:2833 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2833 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9785 | 0.002 |
| Accuracy | 0.9392 | 0.0042 |
| Sensitivity | 0.9596 | 0.0049 |
| Specificity | 0.9181 | 0.0043 |
| BEDROC | 0.9988 | 5.3148 × 10-4 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8896 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9466 | N/A |