TargetNet
P49356
Protein farnesyltransferase subunit beta
Function
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X.
Database Links
| Database | Links |
|---|---|
| UniProt | P49356 |
| PDB | 1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37 |
| BioGrid | 108627 |
| BindingDB | P49356 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA28202 |
| KEGG | hsa:2342 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2342 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9853 | 0.001 |
| Accuracy | 0.9449 | 0.0022 |
| Sensitivity | 0.9535 | 0.004 |
| Specificity | 0.937 | 0.0022 |
| BEDROC | 0.9893 | 0.0031 |
| MCC Threshold | 0.356 | N/A |
| MCC | 0.8886 | N/A |
| F-score Threshold | 0.356 | N/A |
| F-score | 0.9428 | N/A |