TargetNet
P49355
Protein farnesyltransferase subunit beta
Function
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C- terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P49355 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P49355 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:327686 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 327686 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9933 | 7.6286 × 10-4 |
| Accuracy | 0.9676 | 0.0029 |
| Sensitivity | 0.9683 | 0.0042 |
| Specificity | 0.9669 | 0.0071 |
| BEDROC | 1 | 6.0745 × 10-6 |
| MCC Threshold | 0.528 | N/A |
| MCC | 0.9321 | N/A |
| F-score Threshold | 0.476 | N/A |
| F-score | 0.9682 | N/A |