TargetNet
P49286
Melatonin receptor type 1B
Function
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P49286 |
| PDB | Not available |
| BioGrid | 110640 |
| BindingDB | P49286 |
| DrugBank | DB00980 |
| Guide to PHARMACOLOGY | 288 |
| PharmGKB | PA31268 |
| KEGG | hsa:4544 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4544 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9927 | 0.0011 |
| Accuracy | 0.9748 | 0.0023 |
| Sensitivity | 0.973 | 0.005 |
| Specificity | 0.9766 | 0.0026 |
| BEDROC | 0.9995 | 4.6268 × 10-4 |
| MCC Threshold | 0.64 | N/A |
| MCC | 0.9545 | N/A |
| F-score Threshold | 0.64 | N/A |
| F-score | 0.9767 | N/A |