TargetNet
P49146
Neuropeptide Y receptor type 2
Function
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Database Links
| Database | Links |
|---|---|
| UniProt | P49146 |
| PDB | 2IK3 |
| BioGrid | Not available |
| BindingDB | P49146 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 306 |
| PharmGKB | PA31741 |
| KEGG | hsa:4887 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4887 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9314 | 0.0034 |
| Accuracy | 0.8857 | 0.0066 |
| Sensitivity | 0.8464 | 0.0092 |
| Specificity | 0.9277 | 0.0112 |
| BEDROC | 0.9995 | 1.7708 × 10-4 |
| MCC Threshold | 0.568 | N/A |
| MCC | 0.8077 | N/A |
| F-score Threshold | 0.56 | N/A |
| F-score | 0.8971 | N/A |