TargetNet
P48443
Retinoic acid receptor RXR-gamma
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P48443 |
| PDB | 2GL8 |
| BioGrid | 112170 |
| BindingDB | P48443 |
| DrugBank | DB00459, DB00210, DB00523, DB00926, DB00755 |
| Guide to PHARMACOLOGY | 612 |
| PharmGKB | PA34892 |
| KEGG | hsa:6258 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6258 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9801 | 0.0024 |
| Accuracy | 0.943 | 0.0062 |
| Sensitivity | 0.953 | 0.0083 |
| Specificity | 0.9309 | 0.0109 |
| BEDROC | 0.9644 | 0.0217 |
| MCC Threshold | 0.624 | N/A |
| MCC | 0.8977 | N/A |
| F-score Threshold | 0.424 | N/A |
| F-score | 0.9532 | N/A |