TargetNet
P48147
Prolyl endopeptidase
Function
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
Database Links
| Database | Links |
|---|---|
| UniProt | P48147 |
| PDB | 3DDU |
| BioGrid | 111541 |
| BindingDB | P48147 |
| DrugBank | DB00107 |
| Guide to PHARMACOLOGY | 2395 |
| PharmGKB | PA33730 |
| KEGG | hsa:5550 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5550 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9319 | 0.0099 |
| Accuracy | 0.8762 | 0.0091 |
| Sensitivity | 0.841 | 0.0116 |
| Specificity | 0.906 | 0.0093 |
| BEDROC | 0.9861 | 0.0184 |
| MCC Threshold | 0.496 | N/A |
| MCC | 0.7783 | N/A |
| F-score Threshold | 0.438 | N/A |
| F-score | 0.8787 | N/A |