TargetNet
P48067
Sodium- and chloride-dependent glycine transporter 1
Function
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
Database Links
| Database | Links |
|---|---|
| UniProt | P48067 |
| PDB | Not available |
| BioGrid | 112427 |
| BindingDB | P48067 |
| DrugBank | DB00145 |
| Guide to PHARMACOLOGY | 935 |
| PharmGKB | PA35916 |
| KEGG | hsa:6536 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6536 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9734 | 0.0019 |
| Accuracy | 0.9263 | 0.0033 |
| Sensitivity | 0.9539 | 0.0045 |
| Specificity | 0.8926 | 0.005 |
| BEDROC | 0.9985 | 5.1725 × 10-4 |
| MCC Threshold | 0.478 | N/A |
| MCC | 0.8632 | N/A |
| F-score Threshold | 0.478 | N/A |
| F-score | 0.9396 | N/A |