Melatonin receptor type 1A
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Database | Links |
---|---|
UniProt | P48039 |
PDB | Not available |
BioGrid | 110639 |
BindingDB | P48039 |
DrugBank | DB01065, DB00980 |
Guide to PHARMACOLOGY | 287 |
PharmGKB | PA31267 |
KEGG | hsa:4543 |
BioCyc | Not available |
Entrez Gene (GeneID) | 4543 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9879 | 0.0013 |
Accuracy | 0.958 | 0.0031 |
Sensitivity | 0.9539 | 0.0058 |
Specificity | 0.9616 | 0.0027 |
BEDROC | 0.9993 | 4.8678 × 10-4 |
MCC Threshold | 0.424 | N/A |
MCC | 0.9276 | N/A |
F-score Threshold | 0.424 | N/A |
F-score | 0.9619 | N/A |