TargetNet
P47900
P2Y purinoceptor 1
Function
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
Database Links
| Database | Links |
|---|---|
| UniProt | P47900 |
| PDB | 1Y36 |
| BioGrid | 111067 |
| BindingDB | P47900 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 323 |
| PharmGKB | PA32868 |
| KEGG | hsa:5028 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5028 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9267 | 0.0068 |
| Accuracy | 0.8501 | 0.0138 |
| Sensitivity | 0.8814 | 0.0158 |
| Specificity | 0.823 | 0.0152 |
| BEDROC | 0.9849 | 0.0111 |
| MCC Threshold | 0.63 | N/A |
| MCC | 0.7466 | N/A |
| F-score Threshold | 0.63 | N/A |
| F-score | 0.8636 | N/A |