TargetNet
P47820
Angiotensin-converting enzyme
Function
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P47820 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P47820 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:24310 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24310 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9733 | 0.0039 |
| Accuracy | 0.9228 | 0.0047 |
| Sensitivity | 0.9201 | 0.0112 |
| Specificity | 0.9251 | 0.0034 |
| BEDROC | 0.9959 | 0.0021 |
| MCC Threshold | 0.33 | N/A |
| MCC | 0.8633 | N/A |
| F-score Threshold | 0.33 | N/A |
| F-score | 0.9275 | N/A |