smile	binding.affinity
[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H]	62.75
[H]N1C(=O)N(C2=C([H])C(=C([H])C(C3=C([H])C([H])=C(F)C([H])=C3F)=C2C1([H])[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	2.9
[H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C(C3=C([H])C([H])=C(F)C([H])=C3F)=C3C(=C2[H])N(C(=O)C([H])([H])C3([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]	0.74
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]	4.7
[H]OC([H])([H])C(C1=NN(C(N([H])C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	56
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H]	2400
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.23
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]	1.9
[H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.046
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(N=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.18
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	64
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	26
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	23
[H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.23
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	9.9
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.16
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	64
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.87
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	11
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])S(=O)C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.4
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.1
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	14
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	12
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.798
[H]N(C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	35
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	11
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	8
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]	1.2
[H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C(N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]	0.13
[H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3F)C(=C2[H])C2=C([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	4.3
[H]C1=NC(=O)C(=C2C([H])=C([H])C(SC3=C(F)C([H])=C(F)C([H])=C3[H])=NN12)C1=C(Cl)C([H])=C([H])C([H])=C1Cl	11.4
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	5.9
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]	0.5
[H]N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	790
[H]N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H]	560
[H]N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]	760
[H]N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]	2400
[H]C1=C([H])C([H])=C(SC2=NN(C(=O)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C(F)=C1[H]	140
[H]C1=C([H])C(=O)N(N=C1SC1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H]	310
[H]C1=C([H])C(SC2=NN(C(=O)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])=C([H])C([H])=C1Cl	2000
[H]N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]	3500
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	20
[H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	0.2
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]	2
[H]N1C(=O)N(C2=C(C(=NC(=N2)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	3
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])(C([H])([H])[H])C([H])([H])[H]	1.1
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.8
[H]N1N=C([H])C2=C1C([H])([H])C([H])([H])N(C1=NC3=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N3C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C2([H])[H]	1.9
[H]OC1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl	4
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])OC([H])([H])[H]	2
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]	5.6
[H]N1C(=O)N(C2=C(C(=NC(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	4.2
[H]N1C(=O)N(C2=C(C(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	0.5
[H]N1C(=O)N(C2=C(C(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	1
[H]N1C(=O)N(C2=C(C(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	20
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl	4
[H]N1C(=O)N(C2=C(C(=NC(=N2)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	2
[H]N1C(=O)N(C2=C(C(=NC(=N2)N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	2
[H]N([H])C1=C([H])C2=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl	6
[H]N1C(=O)N(C2=C(C(=C([H])C(OC([H])([H])[H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	1
[H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	2
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]	0.6
[H]N(C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C(N([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.7
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.52
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	3.5
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	0.074
[H]OC1=C([H])C2=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl	2
[H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	0.2
[H]N1C(=O)N(C2=C(C(=NC(SC([H])([H])[H])=N2)C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	10
[H]N1C(=O)N(C2=C(C(=NC(=N2)S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	4.2
[H]N([H])C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl	5.3
[H]OC([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1Cl	168
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	197
[H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	490
[H]C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	5
[H]C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1Cl	9
[H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl	20
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]	98
[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	450
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]	150
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	90
[H]OC(C1=NC(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	470
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]	80
[H]OC1(C2=C([H])C(=C(N2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	130
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]	20
[H]OC1(C2=NC(=C(O2)C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	350
[H]OC1(C2=NC(=C(S2)C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	450
[H]OC1(C2=NC(=C(O2)C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	2000
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C1F	470
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=C([H])C(=C(N2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])=C1F	4
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=NC(=C(N2[H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3O2)C2=C([H])C([H])=NC([H])=C2[H])=C1F	5
[H]N([H])C1=NC(N([H])[H])=C(F)C(N2N=C(C(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])=C1F	210
[H]N1C([H])=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]	800
[H]N1C([H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]	1000
[H]N1C(=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C(F)C(F)=NC(F)=C1F	90
[H]N1N=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]	1300
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=NC(=C(N2[H])C2=C([H])C([H])=C([H])O2)C2=C([H])C([H])=NC([H])=C2[H])=C1F	670
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=NC(=C(O2)C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C1F	400
[H]N([H])C1=C(F)C(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C(F)C(F)=N1	4
[H]N([H])C1=C(F)C(C2=NC(=C(O2)C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C(F)C(F)=N1	2100
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=NC(=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C1F	16
[H]N([H])C1=NC(N([H])[H])=C(F)C(C2=NC(=C(S2)C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C1F	140
[H]C1=NC(=C(S1)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]	800
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]	26
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]	8
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]	49
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]	22
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])=C1[H]	76
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H]	171
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])=C1[H]	9
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])=C1[H]	14
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])=C1[H]	42
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])=C1[H]	270
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]	8
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])=C1[H]	2000
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])=C1[H]	22
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])=C1[H]	208
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=C([H])C(=NC([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	1
[H]N([H])C1=C([H])C(OC([H])([H])[H])=C2C(=NC(=C2C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])N1[H]	1500
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=NC(OC([H])([H])[H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	210
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=NC(SC([H])([H])[H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	457
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=C([H])C(=NC([H])=C1[H])N([H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	8
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=NC(=NC([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	22.5
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=NC([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	990
[H]N1C(=NC2=C3C(N([H])C(=C3C3=C([H])C([H])=NC([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]	22
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]	6
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H]	1000
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2Cl)C([H])=C1[H]	14
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H]	344
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]	570
[H]N([H])C1=NC2=NC(=C(N2C([H])=C1[H])C1=C([H])C(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	2
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1F	380
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]	1800
[H]N1C(=O)N(C2=C([H])C([H])=C(SC3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	470
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	8500
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C(F)C(Cl)=C1[H]	34
[H]N1C(=O)N(C2=C([H])C([H])=C(C([H])=C2C1([H])[H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)C1=C(Cl)C([H])=C([H])C([H])=C1Cl	780
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]	53
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl	180
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl	100
[H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]	150
[H]OC1=C([H])C([H])=C(Cl)C([H])=C1S(=O)(=O)N([H])C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	570
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C2=C(N([H])C(=N2)C([H])([H])[H])C([H])=C1Cl)C1=C(F)C([H])=C(F)C([H])=C1[H]	700
[H]N([H])C(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C(=O)C1=C([H])N=C(N([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	8000
[H]N(C1=C([H])C([H])=C(C([H])=N1)C(=O)C1=C([H])C2=C(N([H])C(=N2)C([H])([H])[H])C([H])=C1Cl)C1=C(F)C([H])=C(F)C([H])=C1[H]	8000
[H]N([H])C(C#CC1=C([H])C([H])=C(Cl)C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	6000
[H]OC1(\C([H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])[H])C(=C2[H])C(=O)C2=C([H])C([H])=C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	1000
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C2=C(N([H])C(=N2)C([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	5000
[H]OC1(C2=NC(=C(S2)C2=C([H])C([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]	4
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])=C(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]	5
[H]OC1(C2=NC(=C(O2)C2=C([H])C([H])=NC(=N2)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	11
[H]N(C1=NC(=C([H])C([H])=N1)N1C(=NC2=C1C([H])=C([H])C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]	6
[H]OC1(C2=NC(=C(O2)C2=C([H])C([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]	15
[H]N(C1=NC(=C([H])C([H])=N1)N1C(=NC2=C1C([H])=C([H])C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]	15
[H]OC1(C2=NC(=C(O2)C2=C([H])C([H])=NC(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	9
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])=C(N=C1C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]	8
[H]OC1(C2=C([H])N(C(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=NC(=N2)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	4
[H]OC1(C2=NC(=C(S2)C2=C([H])C([H])=NC(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	5
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC(=N2)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	2
[H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	7
[H]OC1(C2=C([H])N(C(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C([H])=NC(=N2)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]	29
[H]C1=NC([H])=C([H])C(=C1[H])C1=NN(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])OC([H])([H])C([H])([H])[H]	2430
[H]OC1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]	35
[H]N(C1=NC2=NN([H])C(=C2C([H])=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	14
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=NC(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H]	43
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=NC(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H]	47
[H]N(C1=NC2=NN([H])C(=C2C([H])=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	11
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	58
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	280
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	5
[H]N(C1=NC2=NN([H])C(=C2C([H])=N1)C1=C([H])C(C#CC([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	0.6
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	94
[H]OC(=O)C1=C([H])C(C2=C3C([H])=C([H])C(=NC3=NN2[H])N([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H]	200
[H]OC(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2N=C([H])C(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	7
[H]OC(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=NC(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	19
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2N=C([H])C(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H]	21
[H]N([H])C(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=NC(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	12
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2N=C([H])C(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H]	29
[H]N(C1=NC2=NN([H])C(=C2C([H])=N1)C1=C([H])C(C#CC([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	0.9
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=C([H])C(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H]	33
[H]N([H])C(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2N=C([H])C(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	10
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]	0.7
[H]N([H])C(C#CC1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=C([H])C(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]	20
[H]N([H])C1=NN=C(O1)C1=C([H])C(F)=C(C(F)=C1[H])C1=C2C([H])=C([H])C([H])=C(N2C([H])=C([H])C1=O)C1=C([H])C([H])=C(F)C([H])=C1F	6.8
[H]C1=C([H])C2=C(C(=O)C([H])=C([H])N2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C(F)C([H])=C(C([H])=C1F)C1=NC(=NO1)C([H])([H])[H]	8.8
[H]C1=NN=C(O1)C1=C([H])C([H])=C(F)C(=C1[H])C1=C2C([H])=C([H])C([H])=C(N2C([H])=C([H])C1=O)C1=C([H])C([H])=C(F)C([H])=C1F	14.7
[H]C1=C([H])C2=C(C(=O)C([H])=C([H])N2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C([H])C(=C([H])C([H])=C1F)C1=NN=C(O1)C([H])([H])[H]	13
[H]N([H])C1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(F)C([H])=C([H])C([H])=C2F)C(=N1)C1=C([H])C([H])=C(F)C([H])=C1F	0.6
[H]C1=C([H])C(F)=C(C(F)=C1[H])C1=C2C([H])=C([H])C([H])=C(N2C([H])=C([H])C1=O)C1=C([H])C([H])=C(F)C([H])=C1F	7.1
[H]C1=C([H])C2=C(C(=O)C([H])=C([H])N2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C(F)C([H])=C(C#N)C([H])=C1F	1.5
[H]N([H])C(=O)C1=C([H])C(F)=C(C(F)=C1[H])C1=C2C([H])=C([H])C([H])=C(N2C([H])=C([H])C1=O)C1=C([H])C([H])=C(F)C([H])=C1F	20
[H]C1=C([H])C2=C(C(=O)C([H])=C([H])N2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C(F)C([H])=C(C([H])=C1F)C(=O)OC([H])([H])[H]	1.5
[H]C1=C([H])C2=C(C(=O)C([H])=C([H])N2C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C1=C(F)C([H])=C(C([H])=C1F)C1=NN=C(O1)C([H])([H])[H]	14
[H]C1=NN=C(O1)C1=C([H])C(F)=C(C(F)=C1[H])C1=C2C([H])=C([H])C([H])=C(N2C([H])=C([H])C1=O)C1=C([H])C([H])=C(F)C([H])=C1F	5.3
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]	35
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	126
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]	78.3
[H]N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]	766
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	20.7
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	23
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	34.3
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	41.8
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	31.2
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl	64.7
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C([H])([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	59.7
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	225
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]	38.9
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(Cl)C([H])=C([H])C([H])=C2C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	398
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(Cl)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	74.5
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	376
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	62.3
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	26.2
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F	69.7
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]	45.7
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1Cl	39
[H]N1C(=NC(=C1C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]	66.4
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	27.5
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	284
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]	195
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]	298
FC1=CC=C(OC2=NN3C=CC(=O)C(=C3C=C2)C2=C(F)C=CC=C2F)C(F)=C1	10.85
COC(=O)C1=CC=C(F)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	1.3
CC1=NN=C(O1)C1=CC=C(F)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	2.3
CCCNC(=O)C1=CC=C(F)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	20.5
FC1=CC=C(OC2=NN3C=CC(=O)C(=C3C=C2)C2=CC(=CC=C2F)C(=O)N2CCCC2)C(F)=C1	99
CCCNC(=O)C1=CC=C(C=C)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	2.8
CCCNC(=O)C1=CC=C(CC)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	7.85
COC1=CC=CC=C1C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	8.8
COC(=O)C1=CC=C(OC)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	0.58
CCCNC(=O)C1=CC=C(OC)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	1.6
COC1=CC=C(C=C1C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O)C1=NN=C(C)O1	0.33
COC(=O)C1=CC=C(C=C)C(=C1)C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O	0.58