TargetNet
P46098
5-hydroxytryptamine receptor 3A
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Database Links
| Database | Links |
|---|---|
| UniProt | P46098 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P46098 |
| DrugBank | DB00969, DB01161, DB00604, DB00757, DB00889, DB00370, DB00904, DB00377, DB00721, DB01199 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29555 |
| KEGG | hsa:3359 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3359 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9336 | 0.0031 |
| Accuracy | 0.8784 | 0.0061 |
| Sensitivity | 0.8565 | 0.0046 |
| Specificity | 0.9029 | 0.0092 |
| BEDROC | 0.996 | 0.0029 |
| MCC Threshold | 0.6 | N/A |
| MCC | 0.7826 | N/A |
| F-score Threshold | 0.538 | N/A |
| F-score | 0.8885 | N/A |