TargetNet
P45452
Collagenase 3
Function
Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
Database Links
| Database | Links |
|---|---|
| UniProt | P45452 |
| PDB | 1EUB, 1FLS, 1FM1, 1PEX, 1UC1, 1XUC, 1XUD, 1XUR, 1YOU, 1ZTQ, 2D1N, 2E2D, 2OW9, 2OZR, 2PJT, 2YIG, 3ELM, 3I7G, 3I7I, 3KEC, 3KEJ, 3KEK, 3KRY, 3LJZ, 3O2X, 3TVC, 3ZXH, 456C, 4A7B, 4FU4, 4FVL, 4G0D, 830C |
| BioGrid | 110465 |
| BindingDB | P45452 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1637 |
| PharmGKB | PA30871 |
| KEGG | hsa:4322 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4322 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9791 | 6.1689 × 10-4 |
| Accuracy | 0.9464 | 0.0013 |
| Sensitivity | 0.942 | 0.0022 |
| Specificity | 0.9511 | 0.002 |
| BEDROC | 0.9838 | 0.0025 |
| MCC Threshold | 0.488 | N/A |
| MCC | 0.8978 | N/A |
| F-score Threshold | 0.438 | N/A |
| F-score | 0.9502 | N/A |