P43681

Neuronal acetylcholine receptor subunit alpha-4

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Database Links

Database	Links
UniProt	P43681
PDB	2GVT, 2LLY
BioGrid	107559
BindingDB	P43681
DrugBank	DB00184, DB01273
Guide to PHARMACOLOGY	465
PharmGKB	PA26490
KEGG	hsa:1137
BioCyc	Not available
Entrez Gene (GeneID)	1137

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9457	0.0067
Accuracy	0.8903	0.0115
Sensitivity	0.9019	0.0256
Specificity	0.8805	0.0158
BEDROC	0.9659	0.0194
MCC Threshold	0.486	N/A
MCC	0.8229	N/A
F-score Threshold	0.486	N/A
F-score	0.9048	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Download RData

Positive Set

SMILES string + affinity value (.tsv)

Download TSV

TargetNet