TargetNet
P43235
Cathepsin K
Function
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
Database Links
| Database | Links |
|---|---|
| UniProt | P43235 |
| PDB | 1ATK, 1AU0, 1AU2, 1AU3, 1AU4, 1AYU, 1AYV, 1AYW, 1BGO, 1BY8, 1MEM, 1NL6, 1NLJ, 1Q6K, 1SNK, 1TU6, 1U9V, 1U9W, 1U9X, 1VSN, 1YK7, 1YK8, 1YT7, 2ATO, 2AUX, 2AUZ, 2BDL, 2R6N, 3C9E, 3H7D, 3KW9, 3KWB, 3KWZ, 3KX1, 3O0U, 3O1G, 3OVZ, 4DMX, 4DMY, 7PCK |
| BioGrid | 107893 |
| BindingDB | P43235 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2350 |
| PharmGKB | PA27034 |
| KEGG | hsa:1513 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1513 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.961 | 0.0015 |
| Accuracy | 0.9104 | 0.003 |
| Sensitivity | 0.9095 | 0.0058 |
| Specificity | 0.9112 | 0.0023 |
| BEDROC | 0.9546 | 0.0058 |
| MCC Threshold | 0.41 | N/A |
| MCC | 0.8305 | N/A |
| F-score Threshold | 0.41 | N/A |
| F-score | 0.9107 | N/A |