TargetNet
P43140
Alpha-1A adrenergic receptor
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P43140 |
| PDB | 2F75 |
| BioGrid | Not available |
| BindingDB | P43140 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 22 |
| PharmGKB | Not available |
| KEGG | rno:29412 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 29412 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9566 | 0.0011 |
| Accuracy | 0.8881 | 0.0052 |
| Sensitivity | 0.8497 | 0.0074 |
| Specificity | 0.9217 | 0.005 |
| BEDROC | 0.9981 | 3.4624 × 10-4 |
| MCC Threshold | 0.486 | N/A |
| MCC | 0.7858 | N/A |
| F-score Threshold | 0.446 | N/A |
| F-score | 0.8846 | N/A |