TargetNet
P43119
Prostacyclin receptor
Function
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | P43119 |
| PDB | Not available |
| BioGrid | 111711 |
| BindingDB | P43119 |
| DrugBank | DB01160, DB00917, DB01240, DB01088, DB00929 |
| Guide to PHARMACOLOGY | 345 |
| PharmGKB | PA291 |
| KEGG | hsa:5739 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5739 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9103 | 0.0075 |
| Accuracy | 0.8286 | 0.011 |
| Sensitivity | 0.8497 | 0.017 |
| Specificity | 0.8034 | 0.0216 |
| BEDROC | 0.983 | 0.0052 |
| MCC Threshold | 0.378 | N/A |
| MCC | 0.6947 | N/A |
| F-score Threshold | 0.378 | N/A |
| F-score | 0.8684 | N/A |