TargetNet
P43116
Prostaglandin E2 receptor EP2 subtype
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Database Links
| Database | Links |
|---|---|
| UniProt | P43116 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P43116 |
| DrugBank | DB00770, DB01088 |
| Guide to PHARMACOLOGY | 341 |
| PharmGKB | PA287 |
| KEGG | hsa:5732 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5732 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9105 | 0.0072 |
| Accuracy | 0.8309 | 0.0114 |
| Sensitivity | 0.818 | 0.0155 |
| Specificity | 0.8437 | 0.0175 |
| BEDROC | 0.9783 | 0.0126 |
| MCC Threshold | 0.464 | N/A |
| MCC | 0.7168 | N/A |
| F-score Threshold | 0.4 | N/A |
| F-score | 0.8587 | N/A |