TargetNet
P43088
Prostaglandin F2-alpha receptor
Function
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Database Links
| Database | Links |
|---|---|
| UniProt | P43088 |
| PDB | Not available |
| BioGrid | 111709 |
| BindingDB | P43088 |
| DrugBank | DB00905, DB00654, DB00287 |
| Guide to PHARMACOLOGY | 344 |
| PharmGKB | PA290 |
| KEGG | hsa:5737 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5737 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9243 | 0.0108 |
| Accuracy | 0.8754 | 0.0122 |
| Sensitivity | 0.8513 | 0.0161 |
| Specificity | 0.8969 | 0.0168 |
| BEDROC | 0.9809 | 0.0117 |
| MCC Threshold | 0.528 | N/A |
| MCC | 0.7705 | N/A |
| F-score Threshold | 0.454 | N/A |
| F-score | 0.8793 | N/A |