TargetNet
P42574
Caspase-3
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Database Links
| Database | Links |
|---|---|
| UniProt | P42574 |
| PDB | 1CP3, 1GFW, 1I3O, 1NME, 1NMQ, 1NMS, 1PAU, 1QX3, 1RE1, 1RHJ, 1RHK, 1RHM, 1RHQ, 1RHR, 1RHU, 2C1E, 2C2K, 2C2M, 2C2O, 2CDR, 2CJX, 2CJY, 2CNK, 2CNL, 2CNN, 2CNO, 2DKO, 2H5I, 2H5J, 2H65, 2J30, 2J31, 2J32, 2J33, 2XYG, 2XYH, 2XYP, 2XZD, 2XZT, 2Y0B, 3DEH, 3DEI, 3DEJ, 3DEK, 3EDQ, 3GJQ, 3GJR, 3GJS, 3GJT, 3H0E, 3ITN, 3KJF, 3PCX, 3PD0, 3PD1, 4DCJ, 4DCO, 4DCP, 4EHA, 4EHD, 4EHF, 4EHH, 4EHK, 4EHL, 4EHN, 4JJE, 4JQY, 4JQZ, 4JR0 |
| BioGrid | 107286 |
| BindingDB | P42574 |
| DrugBank | DB01065, DB01017, DB00641 |
| Guide to PHARMACOLOGY | 1619 |
| PharmGKB | PA26087 |
| KEGG | hsa:836 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 836 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9199 | 0.0025 |
| Accuracy | 0.8724 | 0.0043 |
| Sensitivity | 0.8191 | 0.0028 |
| Specificity | 0.9256 | 0.0088 |
| BEDROC | 0.9968 | 0.002 |
| MCC Threshold | 0.76 | N/A |
| MCC | 0.7672 | N/A |
| F-score Threshold | 0.536 | N/A |
| F-score | 0.87 | N/A |