Aldo-keto reductase family 1 member C3
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Database | Links |
---|---|
UniProt | P42330 |
PDB | 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN |
BioGrid | 114196 |
BindingDB | P42330 |
DrugBank | DB01093, DB00157 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA24679 |
KEGG | hsa:8644 |
BioCyc | Not available |
Entrez Gene (GeneID) | 8644 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.952 | 0.0025 |
Accuracy | 0.903 | 0.0056 |
Sensitivity | 0.9151 | 0.0074 |
Specificity | 0.8879 | 0.0096 |
BEDROC | 0.9885 | 0.0137 |
MCC Threshold | 0.522 | N/A |
MCC | 0.8261 | N/A |
F-score Threshold | 0.522 | N/A |
F-score | 0.9222 | N/A |