Glutamate receptor 2
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Database | Links |
---|---|
UniProt | P42262 |
PDB | 2WJW, 2WJX, 2XHD, 3R7X, 3RN8, 3RNN, 3UA8 |
BioGrid | 109148 |
BindingDB | P42262 |
DrugBank | DB00142 |
Guide to PHARMACOLOGY | 445 |
PharmGKB | PA28967 |
KEGG | hsa:2891 |
BioCyc | Not available |
Entrez Gene (GeneID) | 2891 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9467 | 0.0065 |
Accuracy | 0.8939 | 0.013 |
Sensitivity | 0.875 | 0.024 |
Specificity | 0.9107 | 0.0155 |
BEDROC | 0.9896 | 0.0142 |
MCC Threshold | 0.544 | N/A |
MCC | 0.8254 | N/A |
F-score Threshold | 0.544 | N/A |
F-score | 0.9048 | N/A |