TargetNet
P41597
C-C chemokine receptor type 2
Function
Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
Database Links
| Database | Links |
|---|---|
| UniProt | P41597 |
| PDB | 1KAD, 1KP1 |
| BioGrid | Not available |
| BindingDB | P41597 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 59 |
| PharmGKB | PA26167 |
| KEGG | hsa:729230 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 729230 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9845 | 0.0011 |
| Accuracy | 0.9529 | 0.0024 |
| Sensitivity | 0.9589 | 0.0034 |
| Specificity | 0.9476 | 0.0026 |
| BEDROC | 0.9912 | 0.0036 |
| MCC Threshold | 0.502 | N/A |
| MCC | 0.9042 | N/A |
| F-score Threshold | 0.502 | N/A |
| F-score | 0.9496 | N/A |