Mitogen-activated protein kinase kinase kinase 8
Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T helper cell differentiation and IFNG expression in T cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
Database | Links |
---|---|
UniProt | P41279 |
PDB | Not available |
BioGrid | 107719 |
BindingDB | P41279 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 2083 |
PharmGKB | PA30606 |
KEGG | hsa:1326 |
BioCyc | Not available |
Entrez Gene (GeneID) | 1326 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.8714 | 0.008 |
Accuracy | 0.79 | 0.0133 |
Sensitivity | 0.833 | 0.0186 |
Specificity | 0.7375 | 0.0199 |
BEDROC | 0.9814 | 0.0147 |
MCC Threshold | 0.398 | N/A |
MCC | 0.5821 | N/A |
F-score Threshold | 0.346 | N/A |
F-score | 0.822 | N/A |