TargetNet
P41235
Hepatocyte nuclear factor 4-alpha
Function
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine.
Database Links
| Database | Links |
|---|---|
| UniProt | P41235 |
| PDB | 1PZL, 3CBB, 3FS1, 4B7W, 4IQR |
| BioGrid | 109414 |
| BindingDB | P41235 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 608 |
| PharmGKB | PA29349 |
| KEGG | hsa:3172 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3172 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8814 | 0.0068 |
| Accuracy | 0.8145 | 0.0106 |
| Sensitivity | 0.7557 | 0.0105 |
| Specificity | 0.872 | 0.0195 |
| BEDROC | 0.9926 | 0.0034 |
| MCC Threshold | 0.594 | N/A |
| MCC | 0.6692 | N/A |
| F-score Threshold | 0.45 | N/A |
| F-score | 0.8044 | N/A |