TargetNet
P41231
P2Y purinoceptor 2
Function
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Database Links
| Database | Links |
|---|---|
| UniProt | P41231 |
| PDB | 1Z8E |
| BioGrid | 111068 |
| BindingDB | P41231 |
| DrugBank | DB04786 |
| Guide to PHARMACOLOGY | 324 |
| PharmGKB | PA32870 |
| KEGG | hsa:5029 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5029 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.942 | 0.0057 |
| Accuracy | 0.8883 | 0.0112 |
| Sensitivity | 0.8702 | 0.0146 |
| Specificity | 0.9044 | 0.0177 |
| BEDROC | 0.981 | 0.0125 |
| MCC Threshold | 0.558 | N/A |
| MCC | 0.7985 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.8934 | N/A |