TargetNet
P41180
Extracellular calcium-sensing receptor
Function
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P41180 |
| PDB | Not available |
| BioGrid | 107296 |
| BindingDB | P41180 |
| DrugBank | DB01012 |
| Guide to PHARMACOLOGY | 54 |
| PharmGKB | PA26097 |
| KEGG | hsa:846 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 846 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9795 | 0.0013 |
| Accuracy | 0.9406 | 0.0054 |
| Sensitivity | 0.9452 | 0.012 |
| Specificity | 0.9366 | 0.0045 |
| BEDROC | 0.9929 | 0.0024 |
| MCC Threshold | 0.414 | N/A |
| MCC | 0.8896 | N/A |
| F-score Threshold | 0.414 | N/A |
| F-score | 0.9412 | N/A |