TargetNet
P41146
Nociceptin receptor
Function
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Database Links
| Database | Links |
|---|---|
| UniProt | P41146 |
| PDB | 4EA3 |
| BioGrid | 111032 |
| BindingDB | P41146 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 320 |
| PharmGKB | PA31944 |
| KEGG | hsa:4987 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4987 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9893 | 6.7486 × 10-4 |
| Accuracy | 0.9573 | 0.0019 |
| Sensitivity | 0.9637 | 0.0038 |
| Specificity | 0.9517 | 0.0014 |
| BEDROC | 0.9986 | 9.1136 × 10-4 |
| MCC Threshold | 0.532 | N/A |
| MCC | 0.9245 | N/A |
| F-score Threshold | 0.532 | N/A |
| F-score | 0.9599 | N/A |