Kappa-type opioid receptor
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Database | Links |
---|---|
UniProt | P41144 |
PDB | Not available |
BioGrid | Not available |
BindingDB | P41144 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | Not available |
KEGG | Not available |
BioCyc | Not available |
Entrez Gene (GeneID) | 100135587 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9808 | 0.0022 |
Accuracy | 0.9296 | 0.0048 |
Sensitivity | 0.9435 | 0.0078 |
Specificity | 0.9153 | 0.0039 |
BEDROC | 0.9996 | 1.8077 × 10-4 |
MCC Threshold | 0.452 | N/A |
MCC | 0.8531 | N/A |
F-score Threshold | 0.452 | N/A |
F-score | 0.929 | N/A |