P41143

Delta-type opioid receptor

Function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Database Links

Database	Links
UniProt	P41143
PDB	1OZC, 2IQM, 4N6H
BioGrid	111030
BindingDB	P41143
DrugBank	DB00611, DB00318, DB00813, DB00956, DB00327, DB00836, DB00295, DB00844, DB01183, DB00704, DB00497, DB01100, DB00647
Guide to PHARMACOLOGY	317
PharmGKB	PA31942
KEGG	hsa:4985
BioCyc	Not available
Entrez Gene (GeneID)	4985

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9617	0.0033
Accuracy	0.9179	0.0084
Sensitivity	0.8616	0.0115
Specificity	0.9742	0.01
BEDROC	0.9999	1.5255 × 10^-5
MCC Threshold	0.564	N/A
MCC	0.8406	N/A
F-score Threshold	0.404	N/A
F-score	0.9097	N/A

Downloads

R Model Object

Random Forest model object (.RData)

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Positive Set

SMILES string + affinity value (.tsv)

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TargetNet