Macrophage metalloelastase
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Database | Links |
---|---|
UniProt | P39900 |
PDB | 1JIZ, 1JK3, 1OS2, 1OS9, 1RMZ, 1ROS, 1UTT, 1UTZ, 1Y93, 1YCM, 1Z3J, 2HU6, 2JXY, 2K2G, 2K9C, 2KRJ, 2OXU, 2OXW, 2OXZ, 2POJ, 2W0D, 2WO8, 2WO9, 2WOA, 2Z2D, 3BA0, 3EHX, 3EHY, 3F15, 3F16, 3F17, 3F18, 3F19, 3F1A, 3LIK, 3LIL, 3LIR, 3LJG, 3LK8, 3LKA, 3N2U, 3N2V, 3NX7, 3RTS, 3RTT, 3TS4, 3TSK, 3UVC, 4EFS, 4GQL, 4GR0, 4GR3, 4GR8, 4GUY, 4H30, 4H49, 4H76, 4H84, 4I03, 4IJO |
BioGrid | 110464 |
BindingDB | P39900 |
DrugBank | DB00551 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA30870 |
KEGG | hsa:4321 |
BioCyc | Not available |
Entrez Gene (GeneID) | 4321 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9548 | 0.0024 |
Accuracy | 0.8982 | 0.0067 |
Sensitivity | 0.9164 | 0.0031 |
Specificity | 0.8783 | 0.0124 |
BEDROC | 0.9955 | 0.0042 |
MCC Threshold | 0.57 | N/A |
MCC | 0.8365 | N/A |
F-score Threshold | 0.57 | N/A |
F-score | 0.9202 | N/A |