TargetNet
P37059
Estradiol 17-beta-dehydrogenase 2
Function
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.
Database Links
| Database | Links |
|---|---|
| UniProt | P37059 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P37059 |
| DrugBank | DB00157 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29479 |
| KEGG | hsa:3294 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3294 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9847 | 0.0021 |
| Accuracy | 0.9503 | 0.0036 |
| Sensitivity | 0.9579 | 0.0065 |
| Specificity | 0.9427 | 0.0062 |
| BEDROC | 0.9972 | 0.0015 |
| MCC Threshold | 0.454 | N/A |
| MCC | 0.9068 | N/A |
| F-score Threshold | 0.454 | N/A |
| F-score | 0.954 | N/A |