TargetNet
P37058
Testosterone 17-beta-dehydrogenase 3
Function
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
Database Links
| Database | Links |
|---|---|
| UniProt | P37058 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P37058 |
| DrugBank | DB00157 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29480 |
| KEGG | hsa:3293 |
| BioCyc | MetaCyc:HS05461-MONOMER |
| Entrez Gene (GeneID) | 3293 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.975 | 0.0016 |
| Accuracy | 0.9492 | 0.0066 |
| Sensitivity | 0.9647 | 0.0087 |
| Specificity | 0.9317 | 0.0123 |
| BEDROC | 0.9943 | 0.0039 |
| MCC Threshold | 0.454 | N/A |
| MCC | 0.9124 | N/A |
| F-score Threshold | 0.454 | N/A |
| F-score | 0.9592 | N/A |