TargetNet
P36544
Neuronal acetylcholine receptor subunit alpha-7
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Database Links
| Database | Links |
|---|---|
| UniProt | P36544 |
| PDB | 2MAW |
| BioGrid | 107561 |
| BindingDB | P36544 |
| DrugBank | DB00184, DB01273 |
| Guide to PHARMACOLOGY | 468 |
| PharmGKB | PA114, PA26483 |
| KEGG | hsa:1139, hsa:89832 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1139, 89832 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9023 | 0.0046 |
| Accuracy | 0.8252 | 0.0056 |
| Sensitivity | 0.8424 | 0.0125 |
| Specificity | 0.8068 | 0.0101 |
| BEDROC | 0.977 | 0.0047 |
| MCC Threshold | 0.656 | N/A |
| MCC | 0.6725 | N/A |
| F-score Threshold | 0.478 | N/A |
| F-score | 0.8345 | N/A |