TargetNet
P35869
Aryl hydrocarbon receptor
Function
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.
Database Links
| Database | Links |
|---|---|
| UniProt | P35869 |
| PDB | Not available |
| BioGrid | 106699 |
| BindingDB | P35869 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA24641 |
| KEGG | hsa:196 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 196 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8585 | 0.014 |
| Accuracy | 0.7724 | 0.014 |
| Sensitivity | 0.7976 | 0.02 |
| Specificity | 0.7463 | 0.0146 |
| BEDROC | 0.8898 | 0.0448 |
| MCC Threshold | 0.38 | N/A |
| MCC | 0.6159 | N/A |
| F-score Threshold | 0.38 | N/A |
| F-score | 0.8231 | N/A |