TargetNet
P35610
Sterol O-acyltransferase 1
Function
Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
Database Links
| Database | Links |
|---|---|
| UniProt | P35610 |
| PDB | Not available |
| BioGrid | 112529 |
| BindingDB | P35610 |
| DrugBank | DB00973, DB01094 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA36015 |
| KEGG | hsa:6646 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6646 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9918 | 6.0504 × 10-4 |
| Accuracy | 0.9693 | 0.0018 |
| Sensitivity | 0.9549 | 0.0042 |
| Specificity | 0.9821 | 0.0013 |
| BEDROC | 0.9998 | 5.0588 × 10-5 |
| MCC Threshold | 0.492 | N/A |
| MCC | 0.9431 | N/A |
| F-score Threshold | 0.492 | N/A |
| F-score | 0.9694 | N/A |