TargetNet
P35563
5-hydroxytryptamine receptor 3A
Function
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Database Links
| Database | Links |
|---|---|
| UniProt | P35563 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P35563 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:79246 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 79246 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9437 | 0.0053 |
| Accuracy | 0.9006 | 0.0036 |
| Sensitivity | 0.8596 | 0.0087 |
| Specificity | 0.935 | 0.0046 |
| BEDROC | 0.9987 | 6.894 × 10-4 |
| MCC Threshold | 0.474 | N/A |
| MCC | 0.8054 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.8947 | N/A |