TargetNet
P35463
Endothelin B receptor
Function
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P35463 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P35463 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | ssc:414911 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 414911 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9574 | 0.006 |
| Accuracy | 0.901 | 0.0087 |
| Sensitivity | 0.9163 | 0.0123 |
| Specificity | 0.8868 | 0.01 |
| BEDROC | 0.9733 | 0.0151 |
| MCC Threshold | 0.508 | N/A |
| MCC | 0.8223 | N/A |
| F-score Threshold | 0.508 | N/A |
| F-score | 0.9091 | N/A |