TargetNet
P35439
Glutamate receptor ionotropic, NMDA 1
Function
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Database Links
| Database | Links |
|---|---|
| UniProt | P35439 |
| PDB | 1PB7, 1PB8, 1PB9, 1PBQ, 1Y1M, 1Y1Z, 1Y20, 2A5T, 3Q41, 4KCC, 4KFQ |
| BioGrid | 246573 |
| BindingDB | P35439 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:24408 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24408 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9098 | 0.005 |
| Accuracy | 0.8561 | 0.0044 |
| Sensitivity | 0.8869 | 0.0101 |
| Specificity | 0.8223 | 0.0108 |
| BEDROC | 0.9628 | 0.0119 |
| MCC Threshold | 0.406 | N/A |
| MCC | 0.7229 | N/A |
| F-score Threshold | 0.406 | N/A |
| F-score | 0.8735 | N/A |