TargetNet
P35408
Prostaglandin E2 receptor EP4 subtype
Function
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Database Links
| Database | Links |
|---|---|
| UniProt | P35408 |
| PDB | Not available |
| BioGrid | 111706 |
| BindingDB | P35408 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 343 |
| PharmGKB | PA289 |
| KEGG | hsa:5734 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5734 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9637 | 0.0042 |
| Accuracy | 0.917 | 0.0057 |
| Sensitivity | 0.9219 | 0.0078 |
| Specificity | 0.9119 | 0.0093 |
| BEDROC | 0.9927 | 0.0052 |
| MCC Threshold | 0.516 | N/A |
| MCC | 0.8499 | N/A |
| F-score Threshold | 0.492 | N/A |
| F-score | 0.927 | N/A |