TargetNet
P35398
Nuclear receptor ROR-alpha
Function
Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.
Database Links
| Database | Links |
|---|---|
| UniProt | P35398 |
| PDB | 1N83, 1S0X |
| BioGrid | 112022 |
| BindingDB | P35398 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 598 |
| PharmGKB | PA34630 |
| KEGG | hsa:6095 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6095 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7822 | 0.0066 |
| Accuracy | 0.7097 | 0.0092 |
| Sensitivity | 0.6707 | 0.0198 |
| Specificity | 0.7441 | 0.006 |
| BEDROC | 0.7996 | 0.0154 |
| MCC Threshold | 0.414 | N/A |
| MCC | 0.453 | N/A |
| F-score Threshold | 0.402 | N/A |
| F-score | 0.7349 | N/A |